Adipocyte dysfunction in rats with streptozotocin-nicotinamide-induced diabetes
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چکیده
منابع مشابه
Sulodexide improves endothelial dysfunction in streptozotocin-induced diabetes in rats.
Diabetes mellitus is associated with many complications including retinopathy, nephropathy, neuropathy and angiopathy. Increased cardiovascular risk is accompanied with diabetes-induced endothelial dysfunction. Pharmacological agents with endothelium-protective effects may decrease cardiovascular complications. In present study sulodexide (glycosaminoglycans composed from heparin-like and derma...
متن کاملAntidiabetic and hypolipidemic effects of Dorema aucheri hydroalcoholic leave extract in streptozotocin-nicotinamide induced type 2 diabetes in male rats
Objective(s):The present study investigated the antidiabetic and hypolipidemic properties of Dorema aucheri leave hydroalcoholic extract in nicotinamide-streptozotocin induced type 2 diabetic rats. Materials and Methods: nicotinamide/streptozotocin-induced diabetic rats were supplemented orally with three different doses of D. aucheri (100, 200 and 400 mg/kg BW) or glibenclamide (0.25 mg/kg) f...
متن کاملMetabolic disturbances and defects in insulin secretion in rats with streptozotocin-nicotinamide-induced diabetes.
Rats with diabetes induced by streptozotocin (STZ) and nicotinamide (NA) are often used in animal studies concerning various aspects of diabetes. In this experimental model, the severity of diabetes is different depending on doses of STZ and NA. Moreover, diabetic changes in rats with STZ-NA-induced diabetes are not fully characterized. In our present study, metabolic changes and insulin secret...
متن کاملRole of Nicotinamide in Streptozotocin Induced Diabetes in Animal Models
Diabetes mellitus (DM) is mainly characterized by hyperglycemia [1] with an imbalance of carbohydrate, protein and fat metabolism due to reduced production of insulin from pancreas (defects in insulin secretion), or when insulin cannot be used efficiently by the body (defect in insulin action), or both [1,2]. Two major forms of diabetes are Type I DM (TIDM) and Type II DM (TIIDM). TIDM is also ...
متن کاملMechanisms Underlying Sesamolin-Induced Attenuation of Vascular Dysfunction in Rats With Streptozotocin-Induced Diabetes
Article history: Received: 20 Nov 2010 Revised: 27 Jan 2011 Accepted: 09 Feb 2011
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ژورنال
عنوان ژورنال: International Journal of Experimental Pathology
سال: 2014
ISSN: 0959-9673
DOI: 10.1111/iep.12073